Biography
Bart C. Weimer , Ph.D.
- CIB Director, CIB
- 4700 Old Main Hill
- Logan, UT 84322-4700
- Phone: (435) 797-2753
- Fax: (435) 797-2766
Overview
Dr. Weimer is a Professor of Microbiology in the Department of Nutrition & Food Sciences at Utah State University. He directs the Center for Integrated BioSystems (CIB) and the Center for Microbe Detection & Physiology (CMDP) at Utah State University. He is a recognized expert in microbiology and microbial physiology using genomics and metabolomics. He is specifically focused on microbial genomics, physiology, and infectious agents. Dr. Weimer conducts research in host/microbe interactions, isolation of novel bioactive natural products, and infectious disease agents. As director he is focused on using this expertise to lead the CIB in research, core services, and biotechnology training. He also lends technical support to academia and industry, using biotechnology, genomics and, metabolomics solutions.
Prior to joining USU, he obtained degrees from University of Arizona (B.S., Honors) and Utah State University (Ph.D.) in microbiology. He trained at the University of Melbourne (Australia) as a postdoctoral fellow in genetics and physiology. Dr. Weimer has also held managerial posts in the food industry related to food and flavor systems. He has worked in microbiology for over 15 years and has conducted research for the Department of Defense, Department of Energy, the Air Force, USDA, DMI, and various industrial affiliates in the agricultural sector.
Dr. Weimer has written over 65 peer-reviewed publications, given over 300 presentations, mentored more than 20 advanced students and research fellows, managed over $15 million in research funding, and holds six patents and four trademarks. Currently, he oversees research projects in the CIB and is dedicated to furthering the mission of biotechnology to meet the needs and expectations of society.
Academic & Administrative Experience
| Director | Center for Integrated BioSystems | 2002–present |
| Director | Center for Microbe Detection & Physiology | 1998–present |
| Co-founder | Lactic Acid Bacteria Genome Consortium | 2000–present |
| Professor | Utah State University Nutrition & Food Sciences, College of Agriculture |
2002–present |
| Adjunct Professor | Utah State University Biology Department, College of Science |
2003–present |
| Adjunct Professor | Utah State University Biological Engineering, College of Engineering |
2003–present |
| Adjunct Professor | Xiamen University (China) Biology, College of Life Sciences |
2005–2008 |
| Associate Professor | Utah State University Nutrition and Food Sciences, College of Agriculture |
1997–2002 |
| Assistant Professor | Utah State University Nutrition and Food Sciences, College of Agriculture |
1991–1997 |
| Post Doctoral Fellow | University of Melbourne (Australia) Biochemistry/Genetics |
1990–1991 |
Awards & Honors
| Inducted into Empire Who’s Who | 2003 |
| Inducted into International Who’s Who Historical Society | 2002 |
| Winder Chair in Food Science – USU, Nutrition and Food Sciences | 1996, 2001–2004 |
| Researcher of the Year – USU, College of Family Life | 1995, 1999 |
| President – Institute for Food Technology, Bonneville Section | 1995 |
| Bachelor of Science – University of Arizona, Graduated with Honors | 1986 |
Education
| Utah State University | Ph.D., Nutrition & Food Sciences - Microbiology | 1990 |
| University of Arizona | B.S., Microbiology/Immunology, Honors | 1986 |
| University of Arizona | B.S., Philosophy | 1986 |
Industry Experience
| BioMatrix Solutions | Co-founder & Chief Technical Officer | 2000–2002 |
| AuroTech, Inc. | Microbiology Group Leader | 1989–1990 |
| HyClone Laboratories | Microbiology/Immunology R&D Technician | 1986–1987 |
| University Medical Center | Microbiology Laboratory Technician | 1984–1986 |
Research Focus
- Bacterial metabolism in extreme environments
- Rapid bacterial detection
- Bacterial attachment to host cells
- Metabolomics of amino acid metabolism
- Metabolic engineering of lactic acid and environmental bacteria
- Genomics of bacteria associated with food and the environment
- Genome evolution and stability
Patents
| Year | Author | Title |
| 2003 | B. Weimer | Real time bacterial detection. New Zealand Patent 508172. |
| 2003 | B. Weimer | Ligand-DNA composition for capture and detection of contaminants on a solid surface. U.S. Patent 6,531,278. |
| 2002 | B. Weimer | Real time bacterial detection. Australian Patent 754,077. |
| 2002 | B. Weimer | Real time bacterial detection. U.S. Patent 6,399,317. |
| 1999 | B. Weimer | Reconditioning antibiotic adulterated food products. U.S. Patent 5,998,222. |
Selected Publications
Ganesan, B,. K. Seefeldt, R. Koka, B. Dias, and B. Weimer. 2004. Monocarboxylic acid production by lactococci and lactobacilli. Int. Dairy J. 14:2135-41.
Ganesan, B,. and B. Weimer. 2004. The role of the aminotransferase IlvE in production of branched chain fatty acids by Lactococcus lactis subsp. lactis. App. Environ. Microbiol. 70:638-641.
Ganesan, B,. K. Seefeldt, and B. Weimer. 2004. Fatty acid production by Brevibacterium linens via amino acid utilization. App. Environ. Microbiol. 70:6385-6393.
Xie, Y., L-S Chou, A. Cutler, and B. Weimer. 2004. Expression profile of Lactococcus lactis ssp. lactis IL1403 during environmental stress with a DNA macroarray. App. Environ. Microbiol. 70:6738-6747.
Weimer, B., Y. Xie, L-S. Chou and A. Cutler. 2004. Gene expression arrays in food. Ed. J.-L. Barredo. Microbial Products and Biotransformation. Humana Press, Totowa, NJ USA.
Weimer, B., and B. Dias. 2004. Volatile Sulfur detection in fermented foods. Ed. J.-L. Barredo. Microbial Products and Biotransformation. Humana Press, Totowa, NJ USA.
Walsh, Marie K., Xinwen Wang and Bart C. Weimer. 2001. Optimizing the immobilization of single-stranded DNA onto glass beads. J. Biochem. Biophys. Methods. 47:175-185.
Weimer, B., M. Walsh, C. Beer, X. Wang, and R. Koka. 2001. Solid-phase capture of proteins, spores, and bacteria. Appl. Environ. Microbiol. 67:1300-1307.
Ummadi, M. and B. C. Weimer. 2001. Tryptophan metabolism in Brevibacterium linens BL2. J. Dairy Sci 84:1773?1782.
Chou, L.-S., B. Weimer. 2001. Interaction between glucose and arginine on the acid production in Lactococcus lactis ssp. lactis. Int. Dairy J. 11:253-258.
Rashid, K., and B. Weimer. 2005. The role of academia in biotechnology workforce development. BioProcess International. 3:16-22.
Dias, B., B. Ganesan, and B. C. Weimer. Detection of keto acids by capillary electrophoresis. (submitted).
Dasei, P., P. Champine, and B. C. Weimer. 2005. The antibacterial activity of syringopeptins and rhamnolipids from pseudomonads. (submitted).
Harrington, E. J., B. C. Weimer, and M. K. Walsh. 2005 Immobilized antibody capture of Salmonella. (submitted).
Weimer, B. C., and D. O?Sullivan. Genomics of lactic acid bacteria. ASM Press, Washington DC, USA.
Weimer, B. C. Functional genomics in LAB. In Genomics of lactic acid bacteria. Ed. Bart C. Weimer and D. O?Sullivan. ASM Press, Washington DC, USA.
Weimer, B. C. Lactococcal genomes ? L. lactis and L. cremoris. In Genomics of lactic acid bacteria. Ed. Bart C. Weimer and D. O?Sullivan. ASM Press, Washington DC, USA.
Weimer, B. C. The genome of Brevibacterium linens. In Genomics of lactic acid bacteria. Ed. Bart C. Weimer and D. O?Sullivan. ASM Press, Washington DC, USA.
Weimer, B. C. Gene expression analysis in LAB. In Genomics of lactic acid bacteria. Ed. Bart C. Weimer and D. O?Sullivan. ASM Press, Washington DC, USA.
Weimer, B. C. Improving the flavour of cheese. Woodhead/CRC Press, Cambridge, England.
Weimer, B. C. and B. Ganesan. Amino acid metabolism and cheese flavour. In Improving the flavour of cheese. Ed. Bart C. Weimer, Woodhead/CRC Press, Cambridge, England.
Weimer, B. C., B. Ganesan, and D. Chen. Functional genomics and flavour. In Improving the flavour of cheese. Ed. Bart C. Weimer, Woodhead/CRC Press, Cambridge, England.
Ganesan, B., M. Stuart, and Bart C. Weimer. 2005. Carbohydrate starvation leads to a non-culturable but metabolically active state in Lactococcus lactis. (submitted).
Weimer, B. C., L.?S. Chou, Y. Xie and B. Ganesan. 2005. Genetic and metabolic characterization of arginine metabolism in Lactococcus lactis ssp. lactis ML3. (submitted).
Ghosh, S. and B. Weimer. Determination of sulfate in milk. (submitted).
Dias, B., and B. C. Weimer. Detection of keto acids with capillary electrophoresis in culture supernatants and cheese. J Chrom A (submitted).
Taylor, Bradley J., Bart C. Weimer, Marie K. Walsh. Characterization of immobilized liposomes. (submitted).
Taylor, Bradley J., Yi Xie, Bart C. Weimer, Marie K. Walsh. Characterization of immobilized liposomes containing Escherichia coli?s mechanosensitive channel of large conductance using CLSM. (submitted).
Koka, R., and B. C. Weimer. Rapid detection of extracellular protease from Pseudomonas fluorescens. Int. Dairy J. (accepted).
Koka, R., M. Blake, and B. Weimer. Diversity of lipases of Pseudomonas isolated from milk: possible existence of multiple enzymes. J. Dairy Research (accepted).
Koka, R., and B. C. Weimer. Isolation and characterization of a lipase and an esterase from Pseudomonas fluorescens RO98. (submitted).
Koka, R., M. Hill, and B. C. Weimer. Influence of growth conditions on protease production in Pseudomonas. (submitted).
Ummadi, M. and B. Weimer. Quantitation of aromatic amino acids and tryptophan catabolites from Cheddar cheese. (submitted).
Xie, Yi, A. Cutler, B. Weimer, A. Parfionovas. 2003. Statistical methods for spot detection with macroarray data. Proceedings of the 35th Symposium on the Interface.
Weimer, B., and D. Mills. 2002. Enhancing foods with Functional Genomics. Food Technology 56:184?188.
Ummadi, M. and B. C. Weimer. 2002. Use of capillary electrophoresis-laser induced fluorescence detection to monitor bacterial growth and amino acid utilization J. Chrom. A 964: 243-253.
Klaenhammer, T. Eric Altermann, Fabrizio Arigoni, Alexander Bolotin, Fred Breidt, Jeffrey Broadbent, Raul Cano, Stephane Chaillou, Josef Deutscher, Mike Gasson, Maarten van de Guchte, Jean Guzzo, Trevor Hawkins, Pascal Hols, Robert Hutkins, Michiel Kleerebezem, Jan Kok, Oscar Kuipers, Mark Lubbers, Emmanuelle Maguin, Larry McKay, David Mills, Arjen Nauta, Ross Overbeek, Herman Pel, David Pridmore, Milton Saier, Douwe van Sinderen, Alexei Sorokin, James Steele, Daniel O?Sullivan, Willem de Vos, Bart Weimer, Monique Zagorec, and Roland Siezen. 2002. Discovering lactic acid bacteria by genomics. Antonie van Leeuwenhoek 82:29-58. (note: authorship is alphabetical).
Koka, R., and B. C. Weimer. 2001. Influence of growth condition on phospholipase production in Pseudomonas. J. Dairy Research 68:109?116.
Koka, R., and B. C. Weimer. 2000. Isolation and characterization of a protease from Pseudomonas fluorescens RO98. J. Applied Microbiol. 89:280-288.
Weimer, B., M. Walsh, and X. Wang. 2000. Influence of a polyethylene glycol spacer on antigen capture by immobilized antibodies. J. Biochem. Biophys. Methods. 43(2):107-117.
Koka, R., and B. C. Weimer. 2000. Investigation of the ability of a purified protease from Pseudomonas fluorescens RO98 to de?bitter cheese. Int. Dairy J. 10:75-79.
Seefeldt, K. and B. C. Weimer. 2000. Diversity of sulfur compounds in lactic acid bacteria J. Dairy Sci. 83: 2740-2746.
Weimer, B. 1999. Brevibacteria. In Encyclopedia of Food Microbiology, R. K. Robinson et al. (Ed.), Academic Press, London.
Chou, L.?S., and Bart Weimer. 1999. Isolation and biochemical characterization of acid and bile tolerant Lactobacillus acidophilus. J. Dairy Sci. 82:23?31.
Pederson, J. A., G. J. Mileski, B. C. Weimer, J. L. Steele. 1999. Genetic Characterization of a Cell Envelope-Associated Proteinase from Lactobacillus helveticus CNRZ32. J. Bact. 181:4592?4597.
Dias, B., and B. C. Weimer. 1999. Production of volatile sulfur compounds in Cheddar cheese slurries. International Dairy Journal 9:605?611.
Weimer, B., K. Seefeldt, and B. Dias. 1999. Sulfur metabolism in bacteria associated with cheese. Antonie van Leeuwenhoek 76:247?261.
Otte, J., Y. Ard?, B. Weimer, and J. S?rensen. 1998. Capillary electrophoresis used to measure proteolysis in cheese ? Chapter 3. Bulletin of the International Dairy Federation, Analysis of Milk Proteins.
Steele, J.L., M.E. Johnson, J.R. Broadbent, and B. C. Weimer. 1998. Starter culture attributes which affect cheese flavor development, pp. 157-170. In, Proc. LACTIC '97 conference, Which strains? For which products?
Johnson, M. E., J. L. Steele, J. Broadbent, and B. C. Weimer. 1998. Manufacture of gouda and flavour development in reduced?fat cheddar cheese. Aust. J. Dairy Tech. 53:67.
Stuart, M., L.?S. Chou, and B. C. Weimer. 1998. Influence of carbohydrate starvation on the culturability and amino acid utilization of Lactococcus lactis ssp. lactis App. Environ. Microbiol 65:665?673.
Dias, B., and Bart Weimer. 1998. Conversion of methionine to thiols by lactococci, lactobacilli, and brevibacteria. Appl. Environ. Microbiol. 64:3320?3326.
Dias, B., and Bart Weimer. 1998. Purification and characterization of methionine ?lyase from Brevibacterium linens BL2. Appl. Environ. Microbiol. 64:3327?3331.
Broadbent, J.R., M. Strickland, B. Weimer, M.E. Johnson, and J.L. Steele. 1998. Peptide accumulation and bitterness in Cheddar cheese made using single-strain Lactococcus lactis starters with distinct proteinase specificities. J. Dairy Sci. 81:327.
Gao, S., D?H. Oh, J. Broadbent, M. Johnson, B. Weimer, and J. Steele. 1997. Aromatic amino acid catabolism by lactococci. Le Lait 77:371.
Weimer, B. C., C. Brennand, J. Broadbent, J. Jaegi, M. Johnson, F. Milani, J. Steele, and D. Sisson. 1997. Influence of flavor adjunct bacteria on the flavor and texture of 60% reduced fat Cheddar cheese. Le Lait 77:383.
Blake, M., and B. Weimer. 1997. Rapid and sensitive immunomagnetic detection of Bacillus stearothermophilus spores in food and environmental samples. Appl. Environ. Microbiol. 63:1643.
Broadbent, Jeffery R., Charlotte Brennand, Mark E. Johnson, James L. Steele, Marie Strickland, and Bart C. Weimer. 1997. Contributions by starter and selected adjunct bacteria to flavor development in reduced-fat cheddar cheese. Dairy Industry Int. 62:35?39.
Strickland, M., B. C. Weimer, and J. R. Broadbent. 1996. Capillary electrophoresis separates many compounds found in cheddar cheese. J. Chromatography A 731:305.
M. Blake, R. Koka, B. C. Weimer. 1996. A Semi-Automated Colorimetric Method for the Determination of Lipase Activity in Milk. J. Dairy Sci. 79:1164.
B. Dias, B. C. Weimer. 1995. A semi automated colorimetric method for determination of peptidases in turbid solutions. J. Rapid Methods and Automation in Microbiol. 3:223.
M. Blake, B. C. Weimer, D. McMahon, and P. Savello. 1994. Direct steam processing of extended shelf life milk: sensory and microbial quality. J. Food Prot. 58:1007.
Weimer, B. C., M. Blake. 1994. Lower temperatures for UHT. Aust. Dairy Foods 15:52.
Weimer, B. C., M. Blake. 1994. ESL milk processing and microbiology. Quality Quarterly Spring (Australia).
Weimer, B. C., M. Blake, A.J. Hillier, and B.E. Davidson. 1993. Studies on factory-derivation techniques using Lactococcus lactis ssp. cremoris FG2. Australian Journal of Dairy Technology 48:59.
Weimer, B. 1992. Can antibiotic test kits be useful? USU Cooperative Extension leaflet #265.
Oberg, C.J., B. C. Weimer, L.V. Moyes, R.J. Brown, and G.H. Richardson. 1991. Proteolytic characterization of Lactobacillus delbrueckii ssp. bulgaricus strains by amino acid analysis. J. Dairy Sci. 74:398.
Weimer, B. C., C. J. Oberg, L. V. Moyes, R. J. Brown, and G. H. Richardson. 1989. Comparison of classical ion exchange amino acid analysis and o-phthaldialdhyde methods to characterize proteolysis by Lactobacillus bulgaricus. J. Dairy Sci. 72:2873.